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Home » 5 things to know before markets open on Wednesday
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5 things to know before markets open on Wednesday

Editor-In-ChiefBy Editor-In-ChiefApril 22, 2026No Comments4 Mins Read
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This is CNBC’s Morning Squawk newsletter. Subscribe here to receive future editions in your inbox.

Happy Wednesday. With the volatility in the oil market, I’ve found it helpful to look at this timeline to remind myself of everything that’s happened over the past eight weeks.

Stock futures are rising this morning. All three major indexes ended yesterday’s trading lower.

Here are five important things investors need to know to start their trading day.

1. Grant of extension

U.S. President Donald Trump speaks at the NCAA Collegiate National Champions Day event at the White House on April 21, 2026 in Washington, DC.

Brendan Smialowski AFP | Getty Images

President Donald Trump announced yesterday that he would extend the ceasefire with Iran, saying the Iranian government is “deeply divided.” The suspension of hostilities was previously scheduled to expire today, but President Trump said Tuesday that the ceasefire would last until Tehran presents a “unified offer.”

Here’s what you need to know:

2. Turbulent times

A United Airlines plane takes a taxi at Los Angeles International Airport on April 21, 2026 in Los Angeles, California.

Justin Sullivan | Getty Images

shares of boeing Shares rose more than 3% this morning after the aircraft maker reported a smaller-than-expected loss per share in the first quarter and sales beat expectations. Boeing CEO Kelly Ortberg will appear on CNBC’s “Squawk on the Street” this morning at 9 a.m. ET to discuss the results. Watch live on CNBC or CNBC+.

meanwhile, united airlines The airline yesterday cut its full-year earnings outlook as it grapples with rising fuel costs. Still, shares were up before the bell this morning after United Airlines’ first-quarter profits and revenue beat expectations.

3. Difficult questions

U.S. President Donald Trump’s nominee, U.S. Federal Reserve Chairman Kevin Warsh, attends a Senate Banking, Housing and Urban Affairs Committee confirmation hearing on Tuesday, April 21, 2026 in Washington, DC, USA.

Graham Sloan | Bloomberg | Getty Images

President Trump’s pick to lead the Federal Reserve Board, Kevin Warsh, was roundly criticized by senators during his confirmation hearing yesterday, facing questions about his wealth, stance on artificial intelligence and his ability to be independent of President Trump.

Warsh said he would not lower interest rates solely at President Trump’s request, which the president had never requested directly, and that he would not fire regional Fed presidents. The former Fed president also had to defend his finances and his tenure at the central bank during the 2007-2008 financial crisis.

But as CNBC’s Matt Peterson writes, the topic of Warsh’s plans for “systemic change” at the central bank was barely mentioned.

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4. Newcomer at Best Buy

The Best Buy logo is displayed outside an electronics store in West Hollywood, California, on March 27, 2026.

Patrick T. Fallon | AFP | Getty Images

best buy announced this morning that insider Jason Bonfig will replace CEO Corey Barry, effective October 31st.

Mr. Bonfig joined the company in 1999 and rose from inventory analyst to director of customers, products and fulfillment. As CNBC’s Melissa Repko reports, he will be tasked with boosting sales during a downturn. The 49-year-old is also steering the electronics retailer as the go-to place for consumers looking for products powered by artificial intelligence.

Meanwhile, Barry will remain as a strategic advisor for six months after stepping down as CEO.

5. Access to GLP-1

Amazon GLP-1 treatment

Source: Amazon Inc.

Amazon is further entering the GLP-1 distribution market. Amazon One Medical, the e-commerce giant’s primary care arm, yesterday launched a program aimed at making the blockbuster weight loss drug easier to access.

As CNBC’s Brandon Gomez reports, patients at Amazon Pharmacy will have access to medications such as Novo Nordisk’s Wigoby and other oral GLP-1 alternatives. Amazon said it plans to offer on-demand prescription renewals and expand its same-day delivery network.

While Amazon stock rose in yesterday’s trading, stocks related to the GLP-1 boom include: his and her health, Viking Therapeutics, amgen and septerna I was pulled back.

daily dividend

President Trump told CNBC yesterday that he would focus on which companies have not asked for tariff refunds, saying those who have not asked for them “know me very well.”

“If they don’t, I’ll remember them.”

—CNBC’s Dan Mangan, Kevin Breuninger, Jeff Cox, Sean Conlon, Sam Meredith, Leslie Josephs, Matt Peterson, Melissa Repko and Brandon Gomez contributed to this report.

Davis Giangiulio helped produce this newsletter. Josephine Rozzelle edited this version.

Never miss the most trusted news moments in business news when you choose CNBC as your preferred source on Google.



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